The Northwestern University Multiphoton Center Core was established in 2004. 

Current support: NINDS P-30 Center Core Grant .

Mission Statement  

The mission of the MP Center Core is: 

• to provide equipment, instruction, and technical support for the safe and productive use of multiphoton microscopy and its integration with electrophysiology and molecular uncaging.

• to transfer software development and hardware characterization of imaging workstation systems designed to optimize electical and optical stimulations while recording cellular optical and electrical repsonses.
• to increase access to and understanding of viable imaging and rapid analysis to both stem cell migration and dendrite voltage responses in acute (living) brain slices.

Upcoming 2P Meetings

Wednesday, 14 January 2009, 10:00 - 11:30 AM Location: Ward 5-230 - CANCELED!!!

Presentation: "Imaging Atherosclerotic Plaque Formation in vivo Using Second Harmonic Generation and Two-photon Excitation Fluorescence Microscopy", Weiming Yu, Research Associate Professor, Department of Physiology, Northwestern University.

Wednesday, 11 February, 10:00 - 11:30 AM Location: Ward 5-230

Presentation: "Studying the role of microglia in Alzheimer's disease by fixed tissue and in vivo imaging", Jaime Grutzendler, Assistant Professor, Department of Neurology, Northwestern University.

Wednesday, 18 February 2009, 10:00 - 11:30 AM Location: Ward 5-230

Presentation: "Imaging Atherosclerotic Plaque Formation in vivo Using Second Harmonic Generation and Two-photon Excitation Fluorescence Microscopy", Weiming Yu, Research Associate Professor, Department of Physiology, Northwestern University.

Wednesday, 11 March 2009, 10:00 - 11:30 AM Location: Ward 5-230

Presentation: "Spontaneous oscillations in mitochondrial membrane potential of cultured neurons did not correlate with cytosolic calcium concentration", Dr.Philip Hockberger, Associate Professor, Department of Physiology, Northwestern University.

 Wednesday, 8 April 2009, 10:00 - 11:30 AM Location: Ward 5-230

Presentation: "Live imaging methods to study leukocyte transendothelial migration in vivo and in vitro", Alexei Mikhailov, Research Assistant Professor, Department of Pathology, Feinberg School of Medicine, Northwestern University.

 Wednesday, 13 May 2009, 10:00 - 11:30 AM Location: Ward 5-230

Presentation: "Determining the rules of synaptic Integration in subthalamic nucleus neurons using 2-photon imaging and uncaging", Jeremy Atherton, Research Associate, Department of Physiology, Northwestern University.

 Wednesday, 10 June 2009, 10:00 - 11:30 AM Location: Ward 5-230

Presentation: "High accuracy subwavelength distance measurements: a variable-angle standing-wave total-internal-reflection optical microscope", J. B. Ketterson, Fayerweather Professor, Department of Physics & Astronomy, Northwestern University.

Friday, 31 July 2009, 10:30 - 11:45 AM Location: Ward 5-230

Presentation: "Single Cell Analysis of TMRM Responses at Low and High Dye Concentrations", Andrew Monteith